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Clearance was found to decrease with a corresponding morphine increase in half-life .
The M3G and M6G to morphine AUC ratios also decreased in these subjects, indicating diminished morphine half life morphine mechanism of action morphine cost morphine at end of life morphine metabolic activity .
Renal Impairment Morphine morphine sulfate pharmacokinetics are altered in patients with renal failure .

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